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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Link to relevant study record(s)

Description of key information

Key value for chemical safety assessment

Additional information

The metabolic fate of the test article 2-(morpholinothio)benzothiazole (MBS) in rats was studied using tracer techniques. The compound given orally to rats was rapidly excreted in the urine and faeces. Five urinary metabolites, (2-mercaptobenzothiazole, its three conjugates mercapturate, glucuronide and sulfate, and 2-mercaptobenzothiazole disulfide) were confirmed. 2-mercaptobenzothiazole disulfide was also found as a faecal metabolite. The test compound was partially transformed in the stomach to 2-mercaptobenzothiazole disulfide, which was predominately excreted into faeces. In the liver, the test compound was mainly transformed to 2-mercaptobenzothiazole and its conjugates. The S-glucuronide and S-sulfate conjugates were predominately excreted into bile (Fukuoka 1995).