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EC number: 203-052-4
CAS number: 102-77-2
The metabolic fate of the test article 2-(morpholinothio)benzothiazole
(MBS) in rats was studied using tracer techniques. The compound given
orally to rats was rapidly excreted in the urine and faeces. Five
urinary metabolites, (2-mercaptobenzothiazole, its three conjugates
mercapturate, glucuronide and sulfate, and 2-mercaptobenzothiazole
disulfide) were confirmed. 2-mercaptobenzothiazole disulfide was also
found as a faecal metabolite. The test compound was partially
transformed in the stomach to 2-mercaptobenzothiazole disulfide, which
was predominately excreted into faeces. In the liver, the test compound
was mainly transformed to 2-mercaptobenzothiazole and its conjugates.
The S-glucuronide and S-sulfate conjugates were predominately excreted
into bile (Fukuoka 1995).
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