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Registration Dossier
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EC number: 203-052-4 | CAS number: 102-77-2
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: acceptable well-documented study report which meets basic scientific principles
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
- Report date:
- 1982
Materials and methods
- Principles of method if other than guideline:
- other: Repeated Insult Patch Test modified Shelanski (4 x 4 Method)
- GLP compliance:
- yes
Test material
- Reference substance name:
- 2-(morpholinothio)benzothiazole
- EC Number:
- 203-052-4
- EC Name:
- 2-(morpholinothio)benzothiazole
- Cas Number:
- 102-77-2
- Molecular formula:
- C11H12N2OS2
- IUPAC Name:
- 2-(morpholin-4-ylsulfanyl)-1,3-benzothiazole
- Details on test material:
- N-oxydiethylene-benzothiazole sulphenamide, brown granules
Constituent 1
Test animals
- Species:
- human
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other: no preparation
- Vehicle:
- other: petrolatum
- Controls:
- not required
- Duration of treatment / exposure:
- four consecutive 24 h periods each week, for three consecutive weeks (induction phase)
- Observation period:
- see text field material and methods
- Number of animals:
- 49 volunteers
Results and discussion
In vivo
Results
- Irritation parameter:
- other: primary skin irritation
- Basis:
- other: 49 volunteers
- Time point:
- other: immediate after exposure
- Score:
- 31
- Max. score:
- 49
- Reversibility:
- no data
- Remarks on result:
- other: 31/49 volunteers with positive skin irritation reactions
Any other information on results incl. tables
Irritation:
The test material elicited irritation in 31/49 individuals.This was well over 50 % of the panelists participating in the study. Minimal or moderate erythema was the extent of irritation in seven (7/49) of these individuals, the picture in the remaining 24 individuals was quite different.
Sensitizing:
During induction phase: 24 individuals (24/49) showed intensive or very intense irritation, consisting of erythema, induration, weeping, and extension beyond the margin of the contact site. The characteristics of these responses were consistent with that of a sensitizing effect.
Applicant's summary and conclusion
- Interpretation of results:
- irritating
- Remarks:
- Migrated information
- Executive summary:
The test material elicited irritation in 31/49 individuals (Monsanto Co. 1982).
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