Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-052-4
CAS number: 102-77-2
The test substance showed skin irritating effects in guinea pigs (Wang 1988) and in a Repeated Insult Patch Test with human volunteers (Monsanto 1982). In addition the test substance was classified as eye irritating in New Zealand albino rabbits (Monsanto Co 1973). In consequence, an existing classification with R36/38 (24 ATP)/ eye irritating cat. 2, skin irritating cat. 2 (regulation no. 1272/2008 GHS) is confirmed.
The skin irritation potential of the test substance MBS was evaluated
with guinea pigs in a pre-test for a sensitizing assay. Two animals were
treated with test substance preparations of 0.5 %, 2 %, 5 % and 10 % for
24 hours. Readings of skin reactions were performed at 1, 24 and 48 h
after removal of the test material. The 5% and 10 % test substance
preparation of MBS produced irritant reactions. The 5 % preparation
however, caused a much weaker skin reaction than the 10 % preparation.
The 0.5 % and 2 % concentrations as well as pure white petrolatum failed
to produce any reactions (Wang 1988).
The potential for MBS to cause primary skin irritation and/ or
sensitization was assessed in 49 human volunteers in a well conducted
Repeated Insult Patch Test. The chemical was tested as a 75 %
preparation in petrolatum. The test material elicited irritation in
31/49 individuals (Monsanto 1982a)
The eye irritating potential of the test substance MBS was evaluated in
an eye irritation study with New Zealand albino rabbits (Monsanto Co
1973). 100 mg of the finely ground test substance was applied into the
conjuntival sac of the rabbits. A 7-day observation period followed the
application of the test substance. Eye response were scored in
accordance with the Federal Hazardous substances Act (F.H.S.A.), 21 CFR,
§ 191.12 (1964).
The test substance was slight to moderate irritating to the rabbit eye
(irritation mean score at 24, 48, and 72 hours: 6/110.0). Effects on the
conjunctivae were noted in all animals at 24 hours (mean score 24 h:
12/110) but were reversible within 120 hours. The test substance was
classified as an eye irritant according to F.H.S.A.
Based on the findings of the above mentioned in vivo studies (see above)
the test substance MBS is classified as skin irritant and eye irritant
according to the classification criteria 67/548/EWG and regulation no.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Šajā tīmekļa vietnē tiek izmantoti sīkfaili, lai nodrošinātu Jums vislabāko lietojumu mūsu tīmekļa vietnēs.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again