Registration Dossier
Registration Dossier
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EC number: 203-052-4 | CAS number: 102-77-2
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: limited but acceptable documented study report which meets basic scientific principles
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 973
Materials and methods
- Principles of method if other than guideline:
- other: eye irritation study
- GLP compliance:
- no
Test material
- Reference substance name:
- 2-(morpholinothio)benzothiazole
- EC Number:
- 203-052-4
- EC Name:
- 2-(morpholinothio)benzothiazole
- Cas Number:
- 102-77-2
- Molecular formula:
- C11H12N2OS2
- IUPAC Name:
- 2-(morpholin-4-ylsulfanyl)-1,3-benzothiazole
- Details on test material:
- Santocure MOR, Lot no. NC 01-001
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Duration of treatment / exposure:
- 24 h
- Observation period (in vivo):
- up to 168 h
- Number of animals or in vitro replicates:
- 6
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 24, 48, 72 h
- Score:
- 6
- Max. score:
- 110
- Reversibility:
- fully reversible within: 120 h
- Remarks on result:
- other: classed as an eye irritant according to F.H.S.A.
Any other information on results incl. tables
Immediate: Slight discomfort
10 min.: moderate to severe erythema, copious discharge
1 h: moderate to severe erythema, copious discharge
24 h: severe erythema, copious discharge containing whitish exudate (mean score 12/110)
48 to 72 h: gradual improvement (mean score 5 and 1 at 48 h and 72 h, respectively)
168 h: all scored zero
168 h mean score: 0
Effects reversible within 168 h
Classed as an eye irritant according to Federal Hazardous substances Act (F.H.S.A.)
Applicant's summary and conclusion
- Interpretation of results:
- irritating
- Remarks:
- Migrated information
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