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EC number: 203-052-4
CAS number: 102-77-2
Clinical observations: during the dosing phase there was a low incidence
of discharge (dried blood) around the nose. Although sequalae were
noted, no physical abnormalities were observed during the test period
that could be ascribed to the administration of the test material.
Body weight and body weight gain: no effects
Organ weight/body weight ratio
Stomach 125 and 250 mg/kg: significant increased, 500 mg/kg no effects
all other tissue/organ body weight rations: no effects
Gross pathology: no effects
Pregnancy of rats:
pregnancy rates: treated females comparable to control females
range of pregnant rats for mating I: 80 to 100 % and 90 to 95% in the
test groups and 90 and 75% in the controls; no evidence of any
compound-related effect or trend was observed
Positive control group (TEM group): pregnancy rates comparable to
vehicle control (mating I 95 %, mating II: 70 %)
Dominant lethal evaluations
Number of implantation sites
vehicle control mating I: 13.7, mating II: 11.5
positive control: significant decrease in the number of implantation
sites (ca. 23 to 56%)
250 and 500 mg/kg groups: comparable to vehicle control
125 mg/kg bw group increased but was within vehicle control range for
both mating periods
No significant changes was evident in any of the OBTS groups compared to
vehicle controls; the mean number of early fetal deaths per pregnancy
was not affected by OBTS
Positive control TEM: significant increased of early fetal deaths ( 6 to
Late fetal deaths:
No effects in any treatment groups compared to vehicle control
Postimplantation mutation index
No effects of pregnant female rats mated with OBTS treated males
compared to vehicle control
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