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EC number: 255-449-7
CAS number: 41583-09-9
The actual concentration of Melamine during the exposure based on gravimetric analyses is given in Table 1. The mean measured concentration during exposure was 5.19 +/- 0.45 g/m³.
The nominal concentration during exposure was calculated to be 12.3 g/m³, indicating a generation efficiency of 42 % .
The particle size distribution is given in Table 2. Ca. 66% of the particles present at the animals breathing zone had an aerodynamic diameter equal to or smaller than 8.2 µm, whereas ca. 35 % equal to or smaller than 5.0 µm. The Mass Median Aerodynamic Diameters (MMAD) was 6.6 µm with a mean geometric standard deviation of 2.5. These data were essentially the same as obtained during preliminary testing: an MMAD of 6.2 µm with a mean geometric standard deviation of 1.9.
The acute inhalation toxicity of Melamine was observed by nose-only exposure of one group of five male and five female rats to a test atmosphere containing the limit concentration of 5.19 +/- 0.45 g test item per m³ for a single 4 -hour period. The Mass Median Aerodynamic Diameter was 6.6 µm. After exposure the animals were observed for 2 weeks. Clinical examinations resulted in changes in breathing pattern in all animals during the exposure to the test item and in blepharospasm in two females
shortly after the administration. From day 1 onwards until the end of the experiment on day 14 no abnormalities were observed in the animals. Overall body weight gain was considered to be normal and no mortality occurred. On day 14 after the administration all animals were necropsied. Abnormalities at necropsy consisted of lung changes (petechiae, discolouration and white spots) in all animals and thymic changes (unilateral red thymus) in one male.
It was concluded that the 4 -hour LC50 value of Melamine was higher than 5.19 g/m³ for both sexes under the present test conditions.
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