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Toxicological information

Toxicity to reproduction

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Administrative data

Endpoint:
toxicity to reproduction
Remarks:
other: repeated dose toxicity study (13 weeks and carcinogenicity study)
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
secondary source
Title:
Carcinogenesis Bioassay of Melamine (CAS No. 108-78-1) in F344/N Rats and B6C3F1 Mice (Feed Study)
Author:
NTP
Year:
1983
Bibliographic source:
NIH Publication No. 82-2501, NTP TR 245

Materials and methods

Principles of method if other than guideline:
repeated dose toxicity study (13 weeks and carcinogenicity study)
GLP compliance:
not specified
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rat
Sex:
male/female

Administration / exposure

Route of administration:
oral: feed
Duration of treatment / exposure:
cf. 7.5.1 and 7.7
Frequency of treatment:
cf. 7.5.1 and 7.7
No. of animals per sex per dose:
cf. 7.5.1 and 7.7

Results and discussion

Overall reproductive toxicity

Reproductive effects observed:
not specified

Any other information on results incl. tables

cf. 7.5.1 and 7.7 and Endpoint summary of toxicity to reproduction

Applicant's summary and conclusion