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EC number: 255-449-7
CAS number: 41583-09-9
The substance is considered to have no potential for bioaccumulation based on experimental data on melamine in monkey and rat (Liu 2010, Mast 1983, Sugiata 1991).
The toxicokinetic profile is derived from
melamine because both melamine and melamine phosphate have a similar
solubility in water (3.5 and 3.9 g/L at 20 °C). Melamine phosphate is a
salt and dissociation to a melamine cation and phosphate anion occurs in
The available experimental data on melamine
shows that it is partly taken up after ingestion and eliminated in the
urine without metabolism (Mast 1983, Sugiata 1991 and Liu 2010). This is
also supported by investigations on the antineoplastic drug
hexamethylmelamine in rat and man (Worzella 1974). In rhesus monkey,
with a single melamine dose of 1.4 mg/kg bw, a half-life of 4.41
± 0.43 h was determined. The Tmax
was 2.67± 1.16 h.
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