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EC number: 255-449-7
CAS number: 41583-09-9
There are two main reasons why the sensitization potential of melamine
phosphate can be derived from melamine: First, phosphate is an
endogenous substance in the body and present in high concentrations in
food and second, both melamine and melamine phosphate are soluble in
water and have a simalar log Pow.
Melamine was tested for sensitizing properties in guinea pigs
(Seibersdorf 2010). The guinea pig maximization test was performed
according to OECD testing guideline 406 and following the principles of
GLP. None of the animals were sensitized with the highest dose that
could be applied (50% in white petrolatum for epicutaneous application).
No experimental data is available regarding respiratory sensitization.
Dangerous Substance Directive (67/548/EEC)
The available studies are considered reliable and suitable for
classification purposes under 67/548/EEC. As a result the substance is
not considered to be classified for skin sensitization under Directive
67/548/EEC, as amended for the 28th time in Directive 2001/59/EC.
Classification, Labelling, and Packaging Regulation (EC) No. 1272/2008
The available experimental test data are reliable and suitable for
classification purposes under Regulation 1272/2008. As a result the
substance is not considered to be classified for skin sensitization
under Regulation (EC) No. 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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