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EC number: 255-449-7
CAS number: 41583-09-9
According to the Guidelines, the concentrations of the test substance
used for each induction exposure should be well-tolerated systemically
and should be the highest to cause mild-tomoderate skin irritation. The
concentration used for the challenge exposure should be the highest non
irritant one. To obtain the appropriate concentrations of the test
substance for the definitive study, a preliminary test was carried out
with 3 female guinea pigs. FCA was administered intradermally and
immediately afterwards the test substance was applied epicutaneously to
the sites of the intradermal injections to examine possible systemic
toxic effects. 7 days later 4 concentrations of the test substance were
administered epicutaneously to the flanks of the animals.
The modes of application were the same as in the definitive study. The
duration of the epicutaneous exposure was 24 hours. The test substance
was applied incorporated in white petrolatum.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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