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EC number: 255-449-7
CAS number: 41583-09-9
The toxicity of melamine to 3 different microorganisms is low.
As the substance is a salt of phosphate, effects can be read-across from
the cation, which is likely to have the more important effects. Inbiological
systems, phosphate is an abundant in cells and body fluids. In
ecological terms, because of its important role in biological systems,
phosphate is a highly sought-after resource. Thus, read-across from
component CAS Reg.-No. 108-78-1, melamine, is justified. All effect
values are minimum values as the molar ratio anion:cation equals 1.74.
Three old and/or insufficiently reported studies on the toxicity of
melamine to different microorganisms are available. A weight of evidence
approach is applied.
Pagga 1979: Inhibition of respiration of activated sludge: EC20 >1992
Hockenbury 1977: Inhibition of nitrification by Nitrosomonas sp.: EC0,
2h >100 mg/L.
Tillmann 1990: Inhibition of respiration of Pseudomonas putida: EC0
Each of the studies with different endpoints and microorganisms
indicates a low toxicity of melamine. The study of Hockenbury 1977 is
the relatively best reported one and was therefore selected as the lead
study in the weight of evidence approach.
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