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EC number: 203-929-1
CAS number: 112-03-8
The test compound did not cause a
significant increase in the number of revertant colonies with any of the
tester strains either in the absence or in the presence of S-9 Mix. No
dose dependent effect was obtained. The test was performed in two
independent experiments. It was concluded that the test substance not
mutagenic in these bacterial test systems either in the absence or in
the presence of an exogenous metabolizing system.
A study was conducted to determine the in
vitro genetic toxicity of the test substance, C18 TMAC (79.8% active)
according to a method similar to OECD Guideline 471, in compliance with
GLP. Salmonella typhimurium strains TA97, TA98, TA100 and TA1535 were
treated with the test substance using the Ames plate incorporation
method. Tests were carried out in triplicate, both with and without the
addition ofmetabolic activation (S9-mix). The concentration range of the
test substance was 0.8 to 2500 µg/plate. Cytotoxicity was observed at
≥100 µg/plate. Control plates without mutagen showed that the number of
spontaneous revertant colonies was similiar to that described in the
literature. All the positive control compounds gave the expected
increase in the number of revertant colonies. No significant increase in
the frequency of revertant colonies was recorded for any of the
bacterial strains at any of the test substance concentrations tested,
either with or without metabolic activation. Under the study conditions,
the test substance was not mutagenic in Salmonella typhimurium strain
TA97, TA98, TA100 or TA1535, with or without metabolic activation
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