Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-929-1
CAS number: 112-03-8
A study was conducted to determine the oral
acute toxicity of the test substance, C18 TMAC (79.8% active) according
to OECD Guideline 401 and EU Method B.1, in compliance with GLP. The
experiment was performed in Wistar rats. The test substance was
administered as a single dose to 5 female rats per group at 630, 800,
1250 and 2000 mg/kg bw (equivalent to 503, 638, 998 and 1596 mg a.i./kg
bw) and to 5 males rats per group at doses of 800 and 2000 mg/kg bw
(equivalent to 638 and 1596 mg a.i./kg bw, after which animals were
examined for 14 days. Examinations performed were mortality, body
weights, clinical signs and gross necropsy for any macroscopic
abnormalities. In males, there was no mortality at 800 mg/kg bw, however
all animals died at 2000 mg/kg bw. In females, only 2 and 3 animals
survived at 630 and 800 mg/kg bw respectively. At 1250 and 2000 mg/kg
bw, all females died. Females, therefore, appeared to be more
susceptible to the effects of treatment than males. Decreased
spontaneous activity, squatting posture, narrowed palpebrae fissures and
irregular respiration were recorded. Also, stupor was observed only in
the animals of the 2000 mg/kg bw group. One female animal of the 800
mg/kg bw group showed blood encrusted lid margin on Day 6 of the study.
All clinical signs were reversible at Day 8 of the study. No effects
were seen on the body weight. The animals killed at the end of the
observation period showed macroscopically visible changes. Under the
study conditions, the LD50 values for the female and male Wistar rats
were determined to be 702.5 and >800 to <2000 mg/kg bw, respectively
(equivalent to 560.5 and >638 to <1596 mg a.i./kg bw, respectively)
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Deze website maakt gebruik van cookies om het surfen zo aangenaam mogelijk te maken.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again