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Physical & Chemical properties

Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
February 16, 2012
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: See 'Justification for type of information'
Justification for type of information:
The study was well conducted according to guidelines and critical micelle concentration (CMC) method was used as an alternative to the water solubility.
Reference:
Composition 1
Qualifier:
according to
Guideline:
other: see 'Principles of method if other than guidelines'
Version / remarks:
critical micelle concentration (CMC) method
Principles of method if other than guideline:
For surface active substances the critical micelle concentration (CMC) method is used as an alternative to the water solubility. The critical micelle concentration (CMC) is determined by measuring the surface tension of test substance solutions at different test substance concentration. For surface active substances which form micelles in solution, the surface tension decreases with increasing concentration until the CMC is reached. At concentrations above the CMC, the surface tension remains constant. The CMC is determined from a plot of the surface tension versus the logarithm of the test substance concentration.

GLP compliance:
no
Type of method:
other: critical micelle concentration (CMC)
Test material information:
Composition 1
Specific details on test material used for the study:
Batch no.: DEG4147039
Purity: 99.2% (w/w)
Appearance: white solid (powder)
Key result
Water solubility:
49 mg/L
Conc. based on:
test mat.
Temp.:
25 °C
pH:
7
Remarks on result:
other: critical micelle concentration (CMC)
Conclusions:
Under the conditions of the study, the water solubility (critical micelle concentration) of the test substance was determined to be 49 mg/L at 25°C.


Executive summary:

A study was conducted to determine the water solubility of the test substance using a guideline based on critical micelle concentration (CMC) method. Test substance solutions at nominal concentrations of 0.0001, 0.001, 0.01, 0.1 and 10 g/L were prepared. The pH of the 10 g/L stock solutions was adjusted by adding 0.1 M sodium hydroxide and monitored with a pH meter. The experiment was performed at 25°C.

The surface tension at 1 g/L solution was determined to be 38 mN/m. Under the conditions of the study, the water solubility (CMC) of the test substance was determined to be 49 mg/L at 25 °C (Börjesson, 2012).

Description of key information

The water solubility was determined using a guideline based on critical micelle concentration (CMC) (Börjesson, 2012)

Key value for chemical safety assessment

Water solubility:
49 mg/L
at the temperature of:
25 °C

Additional information