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EC number: 203-929-1
CAS number: 112-03-8
study was conducted to determine the oral repeated dose toxicity of the
test substance, C16 TMAC (24 -26% active in water), according to a
method similar to OECD Guideline 407, in compliance with GLP. Groups of
10 male and female rats were administered 0, 30, 100 and 300 mg/kg
bw/day of test substance by oral gavage for 28 days. The test substance
used was a 24-26% aqueous solution but it is not clear if the doses
mentioned were corrected. There were no treatment-related changes at the
30 and 100 mg/kg bw/day. In the high-dose group there was an increase in
water consumption, changes in the absolute and relative weights of the
adrenals and spleens (in males) without corresponding effects on
haematology, clinical chemistry and histology. The forestomach of the
high-dose group showed few microscopic changes, however animals in the
high-dose recovery group showed a complete and regular regeneration of
the forestomach mucosa. Hence, the forestomach effects were considered
to be due to the irritating properties of the test substance rather than
symptoms of systemic toxicity. Under the study conditions, the rat 28 d
NOEL for systemic effects was considered to be at 100 mg/kg bw/day,
which is corrected to 25 mg a.i./kg bw/day (assuming its not been done
in the study report) (Potokar, 1991).
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