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EC number: 203-929-1
CAS number: 112-03-8
A study was conducted to determine the skin
irritation / corrosion of the test substance, C18 TMAC (79.8% active)
according to OECD Guideline 404 and EU Method B.4, in compliance with
GLP. A paste containing 0.5 g of the test substance (purity of 79.8%)
with 0.3 mL isotonic saline was applied under semi-occlusive patches to
the clipped dorsal area of four rabbits. One animal was exposed for 4 h
and three animals were exposed for 3 min. The test sites were examined
for evidence of primary irritation and scored according to Draize
method. No signs of irritation were observed during the whole
observation period after exposure to 3 min. However, a 4 h exposure
resulted in slight to well defined erythema and a slight oedema, visible
30-60 min up to 22 days after removal of the plaster. Between one and
seven days after application, slight oedema was noted. During the
observation period, the treated skin area was sporadically dry, rough,
indurated, encrusted, chapped and discoloured. Twenty-two days after
application, pink coloured new skin and a scar was noted. Under the
study conditions, the test substance was found to be corrosive to rabbit
skin (Kreiling, 1996).
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