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EC number: 200-864-0
CAS number: 75-35-4
Table 1: Grossly observed tumors in
rats given vinylidene chloride in drinking water for 2 years
No. animals with tumors (or number of tumors/number of animals)
Percent of animals with tumors
Subcutaneous tumor (mammary and mid-cervical region)
Subcutaneous tumor (eye, ear, and head region)
Subcutaneous tumor (body or limb region)
Nodular proliferation in Iiver (primary site)
Liver (metastatic foci)
Liver (diffuse tumor infiltrate and enlarged, associated with lymphoid)
Kidney (primary site)
Sprague-Dawley rats were exposed to vinylidene chloride orally in
drinking water at 0, 50, 100 and 200 mg/L for up to 2 years.
The mean daily dosage level in mg/kg based on water consumption were 0,
7, 10 and 20 mg/kg for male and 0, 9, 14 and 30 mg/kg for female,
corresponding to 0, 50, 100 and 200 mg/L, respectively.
The statistically significant hepatocellular midzonal fatty change is
considered as a minimal adverse effect in this study. Accordingly, the
NOAEL in male is 10 mg/kg-day and the LOAEL is 20 mg/kg-day; the NOAEL
in female rats is 9 mg/kg-day and the LOAEL is 14 mg/kg-day.
No significant increase in tumor incidence was noticed in this study.
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