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Toxicological information

Neurotoxicity

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Description of key information

Neurotoxicity of vinylidene chloride was assessed in two studies, including one developmental neurotoxicity study, using rats exposed by inhalation. No adverse effect was observed in these studies except a suspected slight effect on the neuromuscular domain at 401 mg/m3.

Key value for chemical safety assessment

Effect on neurotoxicity: via inhalation route

Endpoint conclusion
Dose descriptor:
LOAEC
401 mg/m³

Additional information

1,1 -dichloroethene - at the dose level used (401 mg/m3) - did not clearly affect the different functional domains of the nervous system in adult Wistar rats exposed by inhalation 6 h/day 5 days/week during 65 days. A small adverse effect on the neuromuscular domain, however, cannot be ruled out. The centrilobular hepatocellular hypertrophy observed in the male rats - although (very) slight - was considered an adverse effect of 1,1 -dichloroethene on the liver.

In a developmental neurotoxicity where pregnant CD rats were exposed to vinylidene chloride by inhalation 22-23 h/day from day 8 to 20 of gestation, no evidence of developmental neurotoxicity was observed in pups tested at various times from postnatal day 1 to day

21 in a battery of behavioural tasks, including surface righting, pivoting, auditory startle, bar holding, righting in air, visual placing, swimming ability, physical maturation, and activity, despite maternal and fetal toxicity (reduced bodyweights).

Justification for classification or non-classification

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