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EC number: 200-864-0
CAS number: 75-35-4
The penetration rates were calculated to be
2173, 800.7 and 144.7 µg equiv/cm²/h for the Kp determination, 10- and
60- minute time periods, respectively.
The mean permeability coefficient (Kp) was
0.00178 ± 0.000796 cm/h and the measured absorption values (skin plus
receptor fluid) at 10 and 60 min were 89.9 and 92.2 µg, respectively.
Table 1: Pre and post-dose electrical
impedance (EI) values
Table 2: Percentage of chemical in
donor solution (wash), skin and receptor solution (RF)
The sum of wash, skin and receptor fluid
suggests a low recovery of the applied chemical, primarily for the 10
and 60 min experiments: a significant portion of the applied chemical
evaporated from the skin surface and was retained in a solid matrix
synthetic sorbent trap (Anasorb 747, SKC Inc., USA)
In vitro dermal absorption testing of
vinylidene chloride was undertaken using epidermal membranes from the
abdominal skin of human cadavers mounted in a static diffusion cell
maintained at 32 °C with 0.9 % saline as receptor fluid. Radiolabeled
[14C] vinylidene chloride was applied under infinite dose (1200 µL/cm²)
and occluded conditions. The mean Kp was evaluated at 1.78 x 10-3 ± 7.96
x 10-4 cm/h. There was a moderate loss in skin integrity over the course
of the testing: the ratio of post-EI values to pre-EI values was 0.39.
Short-term dermal penetration experiments
with [14C] vinylidene chloride using the in vitro diffusion cell
method were also conducted under finite dosing (i.e.30 gL/cm²) and
occluded conditions. The short-term penetration rates were calculated to
be 800.7 and 144.7 pg equiv/cm²/h for the 10- and 60- minute time
periods, respectively. There was no loss in skin barrier function in
these experimental conditions (ratio of post-El to pre-El values: 0.97
and 1 .01 for 10 and 60 minutes, respectively).
These results suggest that vinylidene
chloride could potentially be well absorbed by dermal route but these
results must be carefully considered as skin integrity was deteriorated
during the evaluation of permeability coefficient.
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