Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 200-864-0
CAS number: 75-35-4
* Mean of three replicate wells after blank correction
** relative absorbance (rounded values): (100 *(absorbance test
item)/absorbance negative control
A in vitro study was performed to assess the
corrosive potential of 1,1-dichloroethylene by means of the Human Skin
Model Test. Independent duplicate tissues of the human skin model
EST-1000 were exposed to either the test item, the negative control or
the positive control for 3 minutes and 1 hour, respectively. The liquid
test item (50 μL) was applied to each tissue and spread evenly over the
surface of the tissue. A volume of 50 μL of either the negative control
(deionised water) or the positive control (8.0 N KOH) was applied to
each tissue. After exposure to the negative control the absorbance
values exceeded the required acceptability criterion of mean OD570≥0.8
for both treatment intervals thereby confirming the
acceptable quality of the tissues. Exposure to the positive control
induced a decrease in the relative absorbance as compared to the
negative control, both for the 3 minutes exposure period and for the 1
hour exposure period thus confirming the validity of the test system.
After exposure to the test item 1,1-dichloroethylene the relative
absorbance values were decreased to 79.0% after 3 minutes exposure.
After the 1 hour exposure relative absorbance values were reduced to
53.0%. Nevertheless, both values did not exceed the threshold for
corrosivity of 50% (3 minutes) or 15% (1 hour), respectively. Therefore,
the test item was not considered to be corrosive.
In conclusion, it can be stated that in this
study and under the reported experimental conditions, the test item
1,1-dichloroethylene was non corrosive to skin.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Šajā tīmekļa vietnē tiek izmantoti sīkfaili, lai nodrošinātu Jums vislabāko lietojumu mūsu tīmekļa vietnēs.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again