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EC number: 200-864-0
CAS number: 75-35-4
* Mean of three replicate wells after blank correction
** relative absorbance (rounded values): (100 *(absorbance test
item)/absorbance negative control
A in vitro study was performed to assess the
corrosive potential of 1,1-dichloroethylene by means of the Human Skin
Model Test. Independent duplicate tissues of the human skin model
EST-1000 were exposed to either the test item, the negative control or
the positive control for 3 minutes and 1 hour, respectively. The liquid
test item (50 μL) was applied to each tissue and spread evenly over the
surface of the tissue. A volume of 50 μL of either the negative control
(deionised water) or the positive control (8.0 N KOH) was applied to
each tissue. After exposure to the negative control the absorbance
values exceeded the required acceptability criterion of mean OD570≥0.8
for both treatment intervals thereby confirming the
acceptable quality of the tissues. Exposure to the positive control
induced a decrease in the relative absorbance as compared to the
negative control, both for the 3 minutes exposure period and for the 1
hour exposure period thus confirming the validity of the test system.
After exposure to the test item 1,1-dichloroethylene the relative
absorbance values were decreased to 79.0% after 3 minutes exposure.
After the 1 hour exposure relative absorbance values were reduced to
53.0%. Nevertheless, both values did not exceed the threshold for
corrosivity of 50% (3 minutes) or 15% (1 hour), respectively. Therefore,
the test item was not considered to be corrosive.
In conclusion, it can be stated that in this
study and under the reported experimental conditions, the test item
1,1-dichloroethylene was non corrosive to skin.
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