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EC number: 200-864-0
CAS number: 75-35-4
Table 1: excretion of radioactivity in
rats given a single dose of [14C] vinylidene chloride
Radioactivity excreted (% of dose) (mean±SD)
Table 2: excretion of 14C in the urine
and bile after an intragastric dose of [14C] vinylidene chloride (350
Recovery of 14C (% of dose)
Rats equipped with biliary fistula
Table 3: proportion of the urinary
metabolites of vinylidene chloride in rats
Vinylidene chloride urinary metabolites
% of urinary radioactivity
The biological fate of vinylidene chloride
was studied in rats after a single intravenous, intragastric or
intraperitoneal administration of [14C]compound. The main route of
elimination of 1,1-dichlorethene after intraveneous adminstration is via
lungs. Pulmonary (unchanged vinylidene chloride) and urinary
(metabolites, a part of which are of biliary origin) excretions after a
single oral administration are completed within 3 days. Orally, about 80
% of a low dose (500 µg/kg) is excreted in urine whereas 67 % of a high
dose (350 mg/kg) is excreted unchanged by lungs. The major urinary
metabolites are the thiodiglycollic acid and an
N-acetyl-S-cysteinyl-acetyl derivative. The liver and kidneys are the
major organs exposed to radioactive compounds.
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