Registration Dossier

Administrative data

Description of key information

1,1-dichloroethene is identified as being not irritating to skin,  and moderately irritating to the eye.

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Respiratory irritation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Additional information

Three in vitro studies according to generally accepted guidelines were conducted to address the irritation/corrosion potential of 1,1-dichloroethene, i.e. the in vitro human skin model corrosion assay, the in vitro human skin model irritation assay and the bovine corneal opacity and permeability (BCOP) assay. Both studies with the human skin model were negative resulting in a assessment of 1,1-dichloroethene as non irritating to the skin. The BCOP assay indicated that 1,1-dichloroethene is a moderate eye irritant.

Older studies with dichloroethene using rabbits were considered as non reliable because the interpretation of these studies is hindered by the fact that the findings in these study can possibly be attributed to the use of phenolic stabilizer, hydroquinone monoethyl ether (MEHQ).


Effects on eye irritation: moderately irritating

Justification for classification or non-classification

Three in vitro studies according to generally accepted guidelines were conducted to address the irritation/corrosion potential of 1,1-dichloroethene, i.e. the in vitro human skin model corrosion assay, the in vitro human skin model irritation assay and the bovine corneal opacity and permeability (BCOP) assay. Both studies with the human skin model were negative resulting in a assessment of 1,1-dichloroethene as non irritating to the skin, therefore no classification of 1,1 -dichloroethene for skin irritation/corrosion was considered necessary. The BCOP assay indicated that 1,1-dichloroethene is a moderate eye irritant, therefore classification of 1,1 -dichloroethene as a eye irritant category 2 (CLP, EU regulation 1272/2008) is considered necessary.