Registration Dossier
Registration Dossier
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EC number: 200-864-0 | CAS number: 75-35-4
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
Warbrick et al. (2001) reported the outcome of a local lymph node assay. 1,1 -dichloroethene failed to induce an increase of the stimulation index above 3 at all tested concentrations . A stimulation index for 1,1 -dichloroethene of 0.91 was observed at the highest tested concentration of 50 %.
Therefore, according to this study, 1,1-dichloroethene is not a dermal sensitizer.
Migrated from Short description of key information:
1,1-dichloroethene, up to 50 % in acetone/olive oil, failed to induce an increase of the stimulation index in the Local Lymph Node Assay.
Respiratory sensitisation
Endpoint conclusion
- Additional information:
No information is available about respiratory sensitisation.
Migrated from Short description of key information:
No information is available about respiratory sensitisation.
Justification for classification or non-classification
Based on the negative results of a local lymph node assay, classification of 1,1 -dichloroethene as a sensitizer is not considered necessary.
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