Registration Dossier
Registration Dossier
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EC number: 200-864-0 | CAS number: 75-35-4
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- No data
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Old study, not fulfilling a guideline. No details on environmental conditions, test conditions, exposure concentrations and results.
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 978
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- At the time of the study, no guideline was available. LD50 values were calculated using Thompson's method (1947) of moving averages and interpolation.
- GLP compliance:
- not specified
- Test type:
- other: no data
Test material
- Reference substance name:
- 1,1-dichloroethylene
- EC Number:
- 200-864-0
- EC Name:
- 1,1-dichloroethylene
- Cas Number:
- 75-35-4
- Molecular formula:
- C2H2Cl2
- IUPAC Name:
- 1,1-dichloroethene
- Details on test material:
- - Name of test material (as cited in study report): Vinylidene chloride
- Source: Imperial Chemical Industries Limited, Mond Division, Runcorn, Cheshire
Before each experiment, stabilizer was removed by washing with alkali and water
- Purity: VDC was of analaR grade or of the next highest quality available
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- other: Alderley Park strain, specific pathogen-free
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation: about 5 weeks old
- Weight at study initiation: 25 g
- Diet (e.g. ad libitum): standard pellet diet
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Details on oral exposure:
- No details
- Doses:
- 5 concentrations
- No. of animals per sex per dose:
- 5 groups of 6 mice (of each sex)
- Details on study design:
- No details
- Statistics:
- LD50 values were calculated respectively for male and female animals from Thompson's (1947) method of moving average and interpolation.
Results and discussion
- Preliminary study:
- Not applicable
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 217 mg/kg bw
- 95% CL:
- >= 201 - <= 235
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 194 mg/kg bw
- 95% CL:
- >= 171 - <= 221
- Mortality:
- No data
- Clinical signs:
- other: No data
- Gross pathology:
- No data
- Other findings:
- No data
Applicant's summary and conclusion
- Interpretation of results:
- other: Data not used for classification; data obtained from rat studies are considered to be more robust and useful for the identification of the acute toxic hazard
- Remarks:
- Criteria used for interpretation of results: not specified
- Conclusions:
- Oral LD50 males = 217 mg/kg bw
Oral LD50 females = 194 mg/kg bw - Executive summary:
In an acute oral toxicity study, groups of 5 weeks old Alderley Park mice (6/sex) were given a single oral dose of vinylidene chloride in corn oil at 5 doses. Oral LD50: Males = 217 mg/kg bw (201-235); Females = 194 mg/kg bw (171-221)
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