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EC number: 200-864-0
CAS number: 75-35-4
TABLE 1 : Fertility
Index (FI) of Rats Ingesting 1,1 -dichloroethene (VDC)
mg/L VDC in the drinking water
Index (FI) = number of females delivering a litter/number of females
placed with a
different from the control value by Fisher's exact probability test, p<0.05.
Survival Index (PSI) Among
Rats Ingesting 1,1 -dichloroethene (VDC)
mg/L VDC in the Drinking Water
Survival Index (PSI) is the number of liveborn pups surviving to 21
of age/number of liveborn pups.
from the control value by the Wilcoxon test as modified by Haseman and
Three generations of Sprague-Dawley rats were exposed to
drinking-water containing nominal 1,1 -dichloroethene concentrations of
0, 50, 100, or 200 mg/L. After 100 days of exposure, the rats were
mated. There were no biologically significant changes in fertility
index, average number of pups per litter, average body weight of pups,
or pup survival at any exposure. Light microscopic examination of the
liver and kidneys revealed an accentuated hepatic lobular pattern and a
minimal degree of hepatocellular fatty change in the F1 rats of the 100
and 200 mg/L groups. Similar hepatocellular fatty changes were observed
in all groups of F2 rats ingesting vinylidene chloride. The
hepatocellular fatty changes as observed in the 50 mg/l groups in
absence of concurrent effects were judged not sufficient to consider the
dose as a NOAEL. Exposure to 1,1-dichloroethene in drinking-water at
concentrations causing mild, dose-related changes in the liver did not
affect the reproductive capacity of rats through three generations,
which produced six sets of litters. The NOAEL for reproductive toxicity
in this study is 200 mg/L, corresponding to an average exposure of 30
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