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EC number: 500-465-4
CAS number: 160901-28-0
1 - 2.5 moles ethoxylated
Slight but significantly reduced straight line velocity (VSL) of
the sperm was without any significant effects on averaged path velocity
(VAP) or total motility. Moreover, in the available subchronic and
chronic toxicity studies on various AES the primary sex organs of the
males and females did not show evidence for treatment-related adverse
effects.The observed reduced triglyceride levels (female) and increased
percentage neutrophil counts (males) were slight and within the range of
the historical control data.
The male F0 generation showed a small but significant reduction in
bodyweight-liver weight ratios, but the corresponding brain related
liver weights and the absolute liver weights developed not in a dose
dependant way. For the F1 generation where similar results were
reported, no dose-response relationship was detected either. No
influence on liver weight development was seen in the F2 generation.
None of the groups revealed any histopathological or clinical-chemical
findings, which could be attributed to hepatotoxicity. This led to the
conclusion that this untypical liver weight reduction was of no
toxicological relevance, additionally underlined by the absence of such
effects in the studies for subchronic toxicity mentioned above.
There was evidence of toxicity on pup development at the top dose
that was characterised by an increase in the time taken for sexual
development of the male (not significant) and female (significant)
offspring.This was investigated in more detail in the developmental
toxicity study up to 1.5 g/kg bw and no effects were noted there.
Considering all these facts the subchronic NOAEL for systemic toxicity
and reproduction toxicity can be set to greater than 300 mg/kg bw.
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