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EC number: 500-465-4
CAS number: 160901-28-0
1 - 2.5 moles ethoxylated
skin sensitization (OECD 406): not sensitizing
No reliable data on sensitisation are available for AES (C9-11, 1-2.5
EO) Na (CAS 160901-28-0). Therefore this endpoint is covered by
read-across to structurally related AES, i.e. AES (C8-10, 1-2.5 EO) Na.
The AES reported within the category show similar structural,
physico-chemical, environmental and toxicological properties. The
approach of grouping different AES for the evaluation of their effects
on human health and the environment was also made by the Danish EPA
(2001) and HERA (2003), supporting the read-across approach between
structurally related AES.
There is one study available addressing the skin sensitising properties
of AES (C8-10, 1-2.5 EO) Na.
The skin sensitizing potential was assessed in a Guinea Pig Maximisation
Test according to OECD Guideline 406 (Z&S, 2013). In this study 10
female guinea pigs were induced by intradermal and epicutaneous
application of the test item at concentrations of 2.5% (intradermal
induction) and 1.5% (epicutaneous induction). Challenge was performed
with 0.5% test item. Vaseline was used as vehicle. The concentrations
were chosen on basis of a preliminary range finding test. In the
positive control group 5 of 5 animals (100%) showed a positive response
at the 24 and 48 h reading. No positive response was observed in animals
of the negative control and test item group at any observation time.
Thus, the test item showed no sensitising potential within this study.
This lack of sensitising properties of AES is also supported by the
evaluation of various AES reported in the HERA report (2003).
Danish EPA - Environmental and Health Assessment of Substances in
Household Detergents and Cosmetic Detergent Products (2001).
Environmental Project No. 615, pp. 24-28
HERA (2003). Human & Environmental Risk Assessment on ingredients of
European household cleaning products Alcohol Ethoxysulphates, Human
Health Risk Assessment Draft, 2003. http: //www. heraproject. com.
Study not required according to Annex VII-X of Regulation (EC) No
The available data on skin sensitisation do not meet the criteria for
classification according to Regulation (EC) No. 1272/2008, and are
therefore conclusive but not sufficient for classification.
No data available for respiratory sensitisation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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