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EC number: 500-465-4
CAS number: 160901-28-0
1 - 2.5 moles ethoxylated
Various, for details see "executive summary"
McDermott et al. (1975) studied the absorption of C16AE3S
and C16AE9S, labelled with14C in the
1-position of the alkyl chain, after oral exposure in man and rats.
Seventy-two hours after administration of C16AE3S,
radioactive material was mainly excreted via urine (man: 80%; rat: 50%)
and to a lesser extent via faeces (man: 9%; rat: 26%) and air (man: 7%;
rat: 12%). For C16AE9S
however, the radioactivity was mainly excreted via faeces (man: 75%;
rat: 82%) and to a lesser extend via urine (man: 4%; rat: 0.6%) and air
(man: 6%; rat: 4%). The length of the ethoxylate portion of an AES
molecule appears to determine the metabolic fate of the compound
following oral administration in both man and rat. There was no evidence
of hydrolysis of the sulphate group or of metabolism of the ethoxylate
portion of the molecule. The major metabolite found in urine had the
x equals either 3 or 9, respectively.
In a similar investigation, Taylor et al. (1978) studied the
metabolic fate of orally, intraperitoneally or intravenously administered14C-C11AE3S
and14C-C12AE3S in the rat. The authors
observed that both compounds were extensively metabolized (ω-,
β-oxidation) with the proportion of radioactivity appearing in urine and
respired air generally independent of the route of administration. Some
sex differences in the proportions of radioactivity excreted in urine
and respired air was seen, but total recoveries for both compounds were
comparable. By the oral route, 67% of the administered radioactivity
with C11AE3S appeared in the urine of male rats
compared to 45% in females; expired air contained 19% and 35% of
administered radioactivity respectively; 4-5% was present in faeces for
both sexes. The major urinary metabolite of C12AE3S
was identified as 2-(triethoxy sulfate) acetic acid, with C11AE3S,
the major urinary metabolite was tentatively identified as
3-(triethoxysulfate) propionic acid.
Following oral exposure, AES is readily absorbed in the
gastrointestinal tract in man and rat and excreted principally via the
urine. The length of the ethoxylate portion in an AES molecule seems to
have an important impact on the biokinetics of AES in humans and in the
rat. Alcohol ethoxysulfates with longer ethoxylate chains (>7-9 EO
units) are excreted at a higher proportion in the faeces. Once absorbed,
AES is extensively metabolized by beta- or omega oxidation.
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