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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
read-across based on grouping of substances (category approach)
Adequacy of study:
key study
Justification for type of information:
Please refer to the category justification provided in the category object.

Data source

Materials and methods

Test material

Constituent 1
Chemical structure
Reference substance name:
Alcohols, C9-11, branched and linear, ethoxylated, sulfates, sodium salts
EC Number:
500-465-4
EC Name:
Alcohols, C9-11, branched and linear, ethoxylated, sulfates, sodium salts
Cas Number:
160901-28-0
Molecular formula:
CnH2n+1(OCH2CH2)mOSO3Na; n = 9 - 11, m = 1 - 2.5
IUPAC Name:
Alcohols, C9-11, branched and linear, ethoxylated, sulfates, sodium salts

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
cornea opacity score
Time point:
24/48/72 h
Remarks on result:
other: Serious eye damage based on all available eye irritation data in the Alkyl Ether Sulfates (AES) category.
Irritation parameter:
iris score
Time point:
24/48/72 h
Remarks on result:
other: Serious eye damage based on all available eye irritation data in the Alkyl Ether Sulfates (AES) category.
Irritation parameter:
conjunctivae score
Time point:
24/48/72 h
Remarks on result:
other: Serious eye damage based on all available eye irritation data in the Alkyl Ether Sulfates (AES) category.
Irritation parameter:
chemosis score
Time point:
24/48/72 h
Remarks on result:
other: Serious eye damage based on all available eye irritation data in the Alkyl Ether Sulfates (AES) category.

Any other information on results incl. tables

For a detailed assessment of the eye irritation potential of the Alkyl Ether Sulfates (AES) category, please refer to the category justification attached to the category object.

Applicant's summary and conclusion

Interpretation of results:
other: Eye damage 1, H318. Classification according to Regulation (EC) No. 1272/2008 (CLP/EU GHS).
Conclusions:
Applying read-across based on grouping of substances (category approach), a potential to induce serious eye damage is predicted for the target substance.
Executive summary:

The available data on eye irritation in the Alkyl Ether Sulfates (AES) category indicate a potential to induce serious eye damage for the target substance. As explained in the category justification, the differences in molecular structure and composition between the target substance and the members of the AES category are unlikely to lead to differences in the eye irritation potential.