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EC number: 201-645-2
CAS number: 85-98-3
test substance, Centralit, was tested in the study for acute dermal
irritation/corrosion. Rabbits (New Zealand Albino breed) were used for
was performed according to Method B.4 - Acute Toxicity: Dermal
Irritation/Corrosion, Council Regulation (EC) No.440/2008, published in
O.J. L 142, 2008.
rabbits were exposed to 0.5 g of test substance, applied onto clipped
skin for 4 hours using a semi-occlusive dressing. Skin reactions were
evaluated after patch removal and observations were made at 1, 24, 48
and 72 hours after exposure.
first the test substance was applied on the skin of one rabbit (test
animal No. 13). Rabbit No. 13 was investigated 3 minutes, 1 hour and 4
hours after application of the test substance.
evidence of a corrosive effect or symptoms of irritation were observed
on the skin after application.
confirmatory test, two others rabbits (rabbit No. 14 and No. 15) were
used with 4-hour exposition period.
symptoms of irritation on the skin were observed. No other signs of
intoxication were observed.
skin irritation was caused by 4-hour exposure to Centralit.
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