Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 201-645-2
CAS number: 85-98-3
Assessment of the toxicokinetic behaviour of the substance from the relevant available information was performed.The evaluation of toxicokinetics is based on information from three sources: - Experimental data of toxicological tests - Literature data obtained from internet - Data from toxicological databases – free and commercial
low acute oral toxicity of Centralit was found, but the absorption to
the mammalian body occurs. At lethal doses the Central nervous system
disturbances, tremors, lethargy, tonic convulsions were seen. There are
marked differences in toxicity between sexes, the males are much more
resistant and they stand alive at doses which are distinctly lethal to
females. If it could be by caused by differences in absorption is
differences in susceptibility to toxic effects of Centralite were noted
also in studies with repeated administration. In these the effect on
neural system of animals is manifested as Straub phenomenon in first
days of administration. This
reaction is similar for animals after application of opiate substance,
e.g. morphine. During next weeks of study, these changes were not
observed any more, which can relate with adaptation of organism of
treated animals to the test substance. Everything written above reads
for females. In males no such distinct reaction was observed. But in
both sexes the effect on liver weight and function, changes in some
blood parameters and plasma enzymes were noted.
of Centralit had no adverse effect to ability of male and female animals
to successfully mate and produce viable offspring. No signs of any
gonadotropic or mutagenic effects were found.
could be concluded that Centralit after oral administration is absorbed
into body of animals, metabolized in liver and either per se or as
metabolites is rapidly distributed to CNS. It is questionable if it
could reach also the reproduction organs.
absorption through skin or eye mucosa is much less probable. Respiratory
tract absorption could occur but the efficiency of this process is not
information was found about the metabolism and elimination of Centralit.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Na ovom portalu koristimo kolačiće kako bismo vam osigurali najbolje iskustvo njegova pregledavanja.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again