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EC number: 201-645-2
CAS number: 85-98-3
The testing strategy for skin irritation was followed:no literature data and studiesassessment of physicochemical properties and pH measurement - approx. 7 (by contact with universal indicator pH strip moistened with water)In vitro skin corrosion test - negative resultIn vitro skin irritation test - negative resultIn vivo skin irritation/corrosion test - negative resultThe testing strategy for eye irritation/corrosion was followed:no literature data and studiesassessment of results of skin irritation/corrosion testsassessment of physicochemical propertiesIn vitro BCOP test - negative resultIn vivo eye irritation/corrosion test - negative result
test substance, Centralit, was tested in the study for acute dermal
irritation/corrosion. Rabbits (New Zealand Albino breed) were used for
was performed according to Method B.4 - Acute Toxicity: Dermal
Irritation/Corrosion, Council Regulation (EC) No.440/2008, published in
O.J. L 142, 2008.
rabbits were exposed to 0.5 g of test substance, applied onto clipped
skin for 4 hours using a semi-occlusive dressing. Skin reactions were
evaluated after patch removal and observations were made at 1, 24, 48
and 72 hours after exposure.
first the test substance was applied on the skin of one rabbit (test
animal No. 13). Rabbit No. 13 was investigated 3 minutes, 1 hour and 4
hours after application of the test substance.
evidence of a corrosive effect or symptoms of irritation were observed
on the skin after application.
confirmatory test, two others rabbits (rabbit No. 14 and No. 15) were
used with 4-hour exposition period.
symptoms of irritation on the skin were observed. No other signs of
intoxication were observed.
skin irritation was caused by 4-hour exposure to Centralit.
test substance, Centralit, was tested for the assessment of eye
irritation/corrosion effects using albino rabbit (New Zealand Albino
test was performed according to the Method B.5 Acute Toxicity: Eye
Irritation/Corrosion. Council Regulation (EC) No.440/2008, published in
O.J. L 142, 2008.
test was performed initially using one animal. Because a corrosive or
severe irritating effects were not observed in initial test, the
response was confirmed using two additional animals.
following changes were observed on eye at 1 hour after application:
conjunctivae – diffuse, crimson colour, individual vessels not easily
discernible in all rabbits and some swelling above normal in one rabbit
(No. 16). At 24, 48 and 72 hours after application no irritating effects
of eye was observed in all animals.
clinical signs of systemic intoxication were detected.
of results after single application demonstrated that the test
substance, Centralit, is not irritating for eye of rabbit.
Justification for selection of skin
irritation / corrosion endpoint:
In vivo study
Justification for selection of eye irritation endpoint:
In vivo study
on the available data, the substance is not classified.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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