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EC number: 201-645-2
CAS number: 85-98-3
Vitro Mammalian Chromosome Aberration Test assayed the test substance
Centralit for the mutagenicity. The performed test was based on EU
Method B.10, Mutagenicity – In Vitro Mammalian Chromosome Aberration
Test, which is analogous to the OECD Test Guideline No. 473.
peripheral blood lymphocytes from healthy donors were used for testing.
The test substance was diluted in dimethylsulfoxide and assayed in doses
of 50 - 5000µg/mL,
which were applied to cultures in volume of 20µL.
were performed without as well as with metabolic activation with a
supernatant of rat liver and a mixture of cofactors.
arrangement given above, the test substance Centralit was non mutagenic
for the human peripheral blood lymphocytes in both experiments without
and with metabolic activation.
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