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EC number: 201-645-2
CAS number: 85-98-3
did not demonstrate mutagenic activity in any of the tests conducted.
Ethylcentralite was not mutagenic in Salmonella Mutagenicity Test using
strains TA97, TA98, TA100 and TA1535 or in Bacterial
Reverse Mutation Test (acc. to EU method B.13/14 analogous to the OECD
TG 471) both in
the presence and absence of S9 metabolic activation and in
In vitro Mammalian Chromosome Aberration Test on the human peripheral
blood lymphocytes without and with metabolic activation and finally
Ethylcentralite was not even mutagenic in the In vitro Mammalian Cell
Gene Mutation Assay (Thymidine Kinase Locus/TK+/-) in mouse
lymphoma L5178Y cells without and with metabolic activation.
Justification for selection of
genetic toxicity endpoint
No study was selected, all studies were negative.
Short description of key information:
Ethyl centralit was tested for mutagenicity:
- in Salmonella typhimurium, using a
preincubation protocol. Test was performed in the absence of exogenous
metabolic activation, and in the presence of liver S-9 from
Aroclor-induced male Sprague-Dawley rats and Syrian hamsters,
Bacterial Reverse Mutation Test
indicator Salmonella typhimurium strains TA 98, TA 100, TA 1535, TA 1537
and one indicator Escherichia coli WP2 uvrA strain were used with
and without metabolic activation using
a supernatant of rat liver S9
- in vitro Mammalian Chromosome Aberration
Test on the human peripheral blood lymphocytes without and with
- in vitro Mammalian
Cell Gene Mutation Assay (Thymidine Kinase Locus/TK+/-)
in mouse lymphoma L5178Y cells without and with metabolic activation
Endpoint Conclusion: No adverse
effect observed (negative)
the available data, the substance is not classified for genetic toxicity.
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