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EC number: 201-645-2
CAS number: 85-98-3
Acute oral toxicity: EU Method B.1, GLP. Adverse effect was observed. Therefore, the acute oral toxicity of Ethyl centralite is moderate.Acute dermal toxicity: EU Method B.3, GLP. No adverse effect was observed. Therefore, the acute dermal toxicity of Ethyl centralite is low.Acute inhalation toxicity: Toxicology Division Procedural Guide USAEHA. No adverse effect was observed. Therefore, the acute inhalation toxicity of Ethyl centralite is low.
The aim of
the study was to investigate acute toxic effects of the test substance
Centralit, after a single oral administration to Wistar rats (females
follows in test protocol No. 0127 (March, the 3rd, 2001), when after
performing of limit test, higher sensitivity for females was found out.
testing was performed according to Regulation of Ministry of health of
the Czech Republic No. 251/1998 Sb., the Method B.1: Acute Oral Toxicity
(per os). This method corresponds with the guideline OECD No. 401 (1987).
to the study results, the value of LD50 (oral) for female rats is 780.9
mg/kg of body weight.
Rats exposed to a nominal concentration of 0.4 mg/L for 8 hours showed
no toxic signs during exposures and for 14 days thereafter. Body weight
gain and organ-to-body weight ratios of the exposed rats compared to the
control rats were not significantly different. No exposure related
histopathologic changes were noted in tissues and organs.
Compound has a low volatility and should present no acute inhalation
hazard from single short term exposure.
No discernible loss of test material from dispersion tube was found.
Rate showed no toxic signs during exposure and 14 days thereafter. Body
weight gain and the organ-to-body weight ratios of liver, kidney, lung,
spleen and testes from exposed rats compared to the control rats were
not significantly different. No exposure related histopathological
changes were noted in tissues and organs.
Compound has a low volatility and should present no hazard at room
temperature due to the inhalation of ethyl centralite vapors.
Compound melted and vaporized from dispersion tube into exposure
chamber, all compound had been dispersed in 80 minutes at a
concentration 198 mg/L. Rats showed no toxic signs during exposure and
14 days thereafter. Body weight gain and the organ-to-body weight ratios
of the exposed rats compared to the control rats were not significantly
different. No exposure related histopathological changes were noted in
tissues and organs.
Vapor presents no acute inhalation hazard from single short term
test substance, Centralit, was tested for acute dermal toxicity using
was performed according to the Method B.3 Acute Toxicity (Dermal),
Council Regulation (EC) No.440/2008, published in O.J. L 142, 2008.
study was performed as limit test: two groups of animals – 5 males and 5
females at the dose of 2000 mg/kg of body weight. The pre-test was
performed with 1 male and 1 female from each group. After end exposure
test substance of these pilot animals, the other animals of the group
test substance was applied on the shaved skin of the test animals in
delivered form for 24 hours.
test animals were observed 14 days after exposure test substance,
afterwards they were sacrificed, and the necropsy for macroscopic
examination of the organs was performed.
test substance applied at the dose of 2000 mg/kg of body weight did not
cause death of animals. No clinical signs of intoxication were observed.
No macroscopic change was diagnosed during pathological examination of
to the results of study, the value of LD50 (dermal) of the test
substance, Centralit, for rats of both sexes is higher than 2000 mg/kg
of body weight.
Justification for selection of acute
toxicity – inhalation endpoint
Only one study available
Justification for selection of acute toxicity – dermal endpoint
Only one study available
on the available data, the substance is classified as Acute Tox.4, H302.
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