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EC number: 224-506-8
CAS number: 4390-04-9
response data for each animal at each observation time up to removal of
each animal from the test
Score at time point / Reversibility
Max. score: 4
Max. score: 2
Max. score: 3
Average 24h, 48h, 72h
Average time (unit) for reversion
c. = completely reversible; = not completely reversible; n. = not
data is being read across from the source study that tested
Hydrocarbons, C14-C17, n-alkanes, ≤2% aromatics based on analogue read
irritant effect of Petrepar-147 was investigated according to the OECD
Guideline No. 405 (1981).
Three albino rabbits were exposed to 0.1 mL
of the test article in one eye. The eyes were examined and the changes
were graded according to a numerical scale 1, 24, 48 and 78 hrs and on
day 4 and 7 after dosing. The eyes were not rinsed after administration
of the test substance.
No corneal damage or iridal inflammation was
observed. Redness and chemosis were observed in all animals, one hour
after instillation. Slight redness was still observed in two animals at
24 hours while slight chemosis was only observed in one rabbit. The eyes
of all rabbits were normal 48 hours after instillation. The mean
individual scores were 0.33/0.33/0.0 for conjunctival redness and
0.33/0.0/0.0 for chemosis.
Petrepar-147 is not considered as irritating
to the eyes according to Annex VI of the Directive 67/548/EEC and CLP
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