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EC number: 224-506-8
CAS number: 4390-04-9
Table 7.2.3/2: Individual bodyweights of
rats dosed dermally with P-147:
Bodyweight (g) at Day
Table 7.2.3/3: Irritant/corrosive response
data for each animal at each observation time
Score at time point
Max. score: 4
Day 9 -14
data is being read across from the source study that tested
Hydrocarbons, C14-C17, n-alkanes, ≤2% aromatics based on analogue read
P-147 was tested for acute dermal toxicity in HC/CFY (remote
Sprague-Dawley) rats in a limit dose assay according to OECD guideline
N°402. The test substance, a liquid, was administered undiluted as
supplied. A 10% total body surface of hair was removed from the
dorso-lumbar region with clippers in every animal. The assay was
conducted on a group of 10 rats (5 males, 5 females) with a dose of 2000
mg/kg b.w. administered by spreading in a single dermal dose (maximum
dose volume of 2.6 mL/kg b.w). After test substance application an
occlusive patch was held in place for 24 hours. Skin was washed with
water at the end of the 24-hour exposure period.
Examinations for mortality, clinical signs and body weight gain were
performed during the 14-day observation period. All surviving animals
were necropsied at the end of the observation period.
No deaths and clinical signs occurred during the observation period.
weight gain was not affected by treatment. At necropsy, macroscopic
examination of main organs showed no abnormalities.
to well-defined and slight oedema was observed at the site of treatment
in all animals. Reversibility was generally observed by day 6 with the
exception of one animal showing slight oedema until Day 9. All rats
developed small, slightly raised erythematous areas at the dose site on
the day 6. Then, small focal scab formations persisted from day 9 to day
15 in all rats except two females which had recovered by day 14. Two
small areas of necrosis were observed at the treatment site on two males
on day 2 but not on day 6 and day 9, respectively.
the acute dermal LD50 was greater than 2000 mg/kg b.w. under the test
conditions, Petrepar P-147 is not classified according to the criteria
of Annex VI to Directive 67/548/EEC and CLP Regulation 1272/2008.
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Tällä verkkosivustolla käytetään evästeitä parhaan mahdollisen käyttäjäkokemuksen varmistamiseksi.
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