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EC number: 224-506-8
CAS number: 4390-04-9
data is being read across from the source study that tested jet fuels
based on analogue read across.
The purpose of these studies was to assess
the percutaneous absorption and cutaneous disposition of topically
applied (25 uL/5 cm2) neat Jet-A, JP-8, and JP-8(100) jet fuels by
monitoring the absorptive flux of the marker components 14C naphthalene
and 4H dodecane simultaneously applied non-occluded to isolated perfused
porcine skin flaps (IPPSF) (a = 4). Absorption of 14C hexadecane was
estimated from JP-8 fuel. Absorption and disposition of naphthalene and
dodecane were also monitored using a nonvolatile JP-8 fraction
reflecting exposure to residual fuel that might occur 24 h after a jet
fuel spill. In all studies, perfusate, stratum corneum, and skin
concentrations were measured over 5 h. Naphthalene absorption had a
clear peak absorptive flux at less than 1 h, while dodecane and
hexadecane had prolonged, albeit significantly lower, absorption flux
profiles. Within JP-8, the rank order of absorption for all marker
components was (mean +/- SEM; % dose) naphthalene (1.17 +/- 0.07)>
dodecane (0.63 +/- 0.04) > hexadecane (0.18 +/- 0.08). The
area under the curve (AUC) was determined to be (mean +/- SEM; %
dose-h/mL): naphthalene (0.0199 +/- 0.0020)> dodecane (0.0107 +/-
0.0009) > hexadecane (0.0017 +/- 0.0003). In contrast, deposition within
dosed skin showed the reverse pattern.
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