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EC number: 224-506-8
CAS number: 4390-04-9
response data for each animal at each observation time up to removal of
each animal from the test
Score at time point / Reversibility
Max. score: 4
L and R: 0/0/0
Average 24h, 48h, 72h
L+R: 0.2 -0.3- 0.5
L and R: 0.7-0-0
Average time (unit) for reversion
within 72 hours
within 7 days
L: left test flank R: right test flank C:
data is being read across from the source study that tested
Hydrocarbons, C14-C18, n-alkanes, isoalkanes, cyclics, ≤2% aromatics
based on analogue read across.
In a primary dermal irritation study
conducted according to OECD guideline N°404, three rabbits were exposed
to 0.5 mL of DEV 98-25 at two skin sites on the back.
Test sites were covered with a
semi-occlusive dressing for 4 hours. Animals then were observed for 7
days. The skin reactions were assessed at 1, 24, 48 and 72 hours, as
well as 7 days after removal of the dressing. The mean score was
calculated across 3 scoring times; 24, 48 and 72 hours after patch
removal, for each animal separately.
The mean individual scores were 0.2, 0.3 and
0.5 for erythema and 0.7, 0.0 and 0.0 for edema.
Based upon the directive 67/548/EEC and the
CLP Regulation 1272/2008, DEV 98 -25 is not considered as irritating to
the rabbit skin.
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