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EC number: 224-506-8
CAS number: 4390-04-9
response data for each animal at each observation time up to removal of
each animal from the test
Score at time point / Reversibility
Max. score: 4
Average 24h, 48h, 72h
Average time (unit) for reversion
c. = completely reversible;= not completely reversible; n. = not
data is being read across from the source study that tested
Hydrocarbons, C16-C20, n-alkanes, isoalkanes, cyclics, <2% aromatics
based on analogue read across.
In a primary dermal irritation study
conducted as similar to OECD guideline N°404 in compliance with GLP, six
young adult female New Zealand White rabbits were dermally exposed to
0.5 mL of MRD-90-903. Test sites were covered with a semi-occlusive
dressing for 4 hours. The skin reactions were assessed at 45 minutes,
24, 48 and 72 hours after removal of the dressing. The mean score was
calculated across 3 scoring times for all animals at 24, 48 and 72 hours
after patch removal.
The mean scores over 24, 48 and 72 hours
were 0.0 for erythema and for oedema.
Based upon the directive 67 /548/EEC and the
CLP Regulation 1272/2008, MRD-90-903 is not considered as irritating to
the rabbit skin.
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