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EC number: 224-506-8
CAS number: 4390-04-9
data is being read across from the source study that tested
Hydrocarbons, C10-C12, isoalkanes <2% aromatics based on analogue read
To assess acute inhalation toxicity, MRD-95
-247 was administered via individual whole-body inhalation chambers for
four hours to two groups of ten Crl:CDBR rats at either an estimated
aerosol concentration of 5247 mg/m3 or an analytical
concentration of 5266 mg/m3 (5213 mg/m3 aersol, 53
mg/m3 vapor). Animals were observed for fourteen days
following exposure. No mortality was observed, and all animals that
received the estimated aerosol concentration of 5247 mg/m3
were free of gross pathological abnormalities. In the second group (5266
mg/m3 aerosol), 4 males and 1 female exhibited red foci on
the lungs, one male displayed dark red nasal turbinates, and 3 males and
1 female had alopecia and/or scabs on the dorsal surface, extremities,
and/or head. Based on the conditions of this study, the LC50 for acute
inhalation exposure to an aerosol atmosphere of MRD-95 -247 is greater
than 5266 mg/m3.
This finding does not warrant classification
of MRD-95-247 as an acute inhalation toxicant under the new Regulation
(EC) 1272/2008 on classification, labeling, and packaging of substances
and mixtures (CLP) or under the Directive 67/518/EEC for dangerous
substances and Directive 1999/45/EC for preparations.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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