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EC number: 224-506-8
CAS number: 4390-04-9
data is being read across from the source study that tested Paraffins
with 8-18 C atoms prepared from unsaturated hydrocarbons
on analogue read across.
Labeled paraffins with 8-18 C atoms prepared
from unsaturated hydrocarbons by addition of deuterium have been added
in oily solution to normal rats’ food. After six days an increase of
deuterium content in the body fluid of all the rats was observed
indicating that the labeled compounds had been metabolized. Deuterium
was found in the fatty acids of the body fats and the liver lipids
especially after feeding octadecane and hexadecane. Isolating oleic,
stearic, and palmitic acids containing deuterium, indicated that methyl-
and beta-oxidation of these hydrocarbons has occurred. Fatty acids
resulting from the metabolism of hydrocarbons with shorter chains were
not deposited but in these cases the urine contained fatty acids with
higher deutrium content than after administration of octadecane and
hexadecane. According to the deuterium content of the neutral fractions
from the liver and body lipids all the hydrocarbons tested were
deposited only to a small extent, the largest depots occurring mainly
after feeding with octadecane and hexadecane.
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