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EC number: 224-506-8
CAS number: 4390-04-9
data is being read across from the source study that tested cyclopentane
based on analogue read across.
Fifteen male and 15 female Wistar rats per
test group were exposed to cyclopentane vapour (pure) at concentrations
of 5, 10, 30 mg/L and cyclopentane vapour (technical grade) at a
concentration of 30 mg/L for 6 hours per weekday for 90 days. A
concurrent control group was exposed to clean air. General observation
were performed twice during weekdays and once during weekends and
holidays. Clinical examinations were performed once every weekday and on
the day following exposure. Neurofunctional test were performed in 10
animals per sex, once before the exposure period and three times during
the exposure period. A hematological and clinicochemical examination was
performed in 10 animals per sex at the end of the exposure period. A
complete necropsy was performed on 10 animals per sex, which included
weighing of selected organs and gross pathological evaluation. 5 animals
per sex, of those subject to neurofunctional testing, were sacrificed by
perfusion fixation and examined neuropathologically. Subchronic
inhalation exposure to up to 30 mg/L of cyclopentane vapour (i.e.,
technical grade or high purity) did not cause a substance related toxic
effect. The NOAEC is 30 mg/L under the conditions of this study.
This study was given a Kilimsh score of 1,
reliable without restriction. The study had minor discrepancies that are
listed in the overall remarks/attachments comment box in this robust
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