Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 224-506-8
CAS number: 4390-04-9
data is being read across from the source study that tested
Hydrocarbons, C10-C13, n-alkanes, <2% aromatics based on analogue read
A Magnusson and Kligman Guinea-Pig
Maximization test was conducted on 30 guinea pigs with MRD-83-205 .
Following a preliminary irritation test, 15 guinea pigs were treated by
intradermal injection (5.0% (v/v) vehicle or adjuvant/ MRD-83-205 ) to
induce sensitization and then further sensitized by dermal application
of 50.0% (v/v) MRD-83-205 . Guinea Pigs were challenged by topical
application (0.5% (v/v) MRD-83-205 in corn oil). All animals survived to
termination of study displaying an increase in weight over the initial
values. There was a very low incidence of clinical
in-life observations noted throughout the test period. Following
topical challenge with 0.5% MRD-83-205, four out of 15 animals in both
the treated and control groups displayed minimal irritation. Based
on the scores of dermal irritation, test substance MRD-83-205 would not
be considered a dermal sensitizer under the EU GHS guidelines or under
the EU requirements for dangerous substances and preparations guidelines.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Tällä verkkosivustolla käytetään evästeitä parhaan mahdollisen käyttäjäkokemuksen varmistamiseksi.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again