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EC number: 275-702-5
CAS number: 71617-10-2
The dose-response of the
test substance isopentyl
p-methoxycinnamate following repeated subcutaneously
administration was examined in an in-vivo uterotrophic screening assay
(three-day treatment) using juvenile female Wistar rats.The study
methodology conformed to the OECD Validation work on in-vivo
uterotrophic screening assay, OECD, Protocol of the conduct of the
rodent uterotrophic assay, Draft protocol B-Immature female rats with
sub-cutaneous administration (April 20, 2000). Groups of 6 juvenile
female rats of the strain HsdCpb:WU were administered isopentyl
p-methoxycinnamate once a day at levels of 0 (untreated), 0
(vehicle control) 20 and 1000 mg/kg bwfor a period of three days. In two
additional groups of 6 juvenile female rats, each of the females were
treated once a day for 3 consecutive days with either 0.3 and 1.0 µg/kg
17alpha-ethinylestradiol (positive control). The vehicle used for all
groups except untreated control was corn oil. Clinical observations were
performed daily. Body weights ware determined daily. Feed intake was
determined per group at termination (day 3). Gross necropsy (with uterus
weights and tissue sampling) was performed on all animals at
Regarding state of health or
general behaviour of the animals, mortality, body weights, and feed
intake, there was no difference between the untreated animals and
animals treated with isopentyl
No effects on uterine weight
were observed at 200 and 1,000 mg/kg isopentyl
p-methoxycinnamate. An enlargement of uterus was observed
and increased uterine weights were determined at 0.3 and 1.0 µg/kg
ethinylestradiol (positive control). In conclusion, no estrogenic
effects were detected in the uterotrophic assay on juvenile female rats
at sub-cutaneous doses of 1000 mg isopentyl
p-methoxycinnamate per kg body weight and below.
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