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EC number: 275-702-5
CAS number: 71617-10-2
After dosing, the animals of all groups treated with the test substance
showed a reduced motility and piloerection. The animals of the highest
dosage showed the most pronounced effect. In the animals of all groups,
the ratio of polychromatic to normochromatic erythrocytes was normal.
The mutagenic effect of the compound isopentyl
p-methoxycinnamate was studied by means of the micronucleus test
in bone marrow cells of NMRI mice.
Male and female mice were treated with one intraperitoneal
injection of the test substance isopentyl p-methoxycinnamate
in olive oil at dose levels of 750, 1500, and 3000 mg/kg and a standard
volume of 10 ml/kg. Bone marrow smears were prepared at 24 h after
treatment. With the highest dosage, additional preparations at 48 and 72
h were made. Each group comprised 5 males and 5 females.
A vehicle control group, consisting of 5 males and 5 females, was
dosed with olive oil. A positive control group, also consisting of 5
males and 5 females, was treated with cyclophosphamide at a dose level
of 50 mg/kg. The animals of both control groups were killed 24 h after
At least 1000 polychromatic erythrocytes per animal were scored
for the incidence of micronuclei. The number of micronucleated
normochromatic erythrocytes was also recorded. The ration of
polychromatic to normochromatic erythrocytes was determined for each
animal by counting a total of 1000 erythrocytes.
Under the test conditions described, the test compound isopentyl
p-methoxycinnamate failed to induce a significant increase in
micronucleated polychromatic erythrocytes compared with the negative
controls at any dose tested. The positive control substance,
cyclophosphamide, however, produced a huge increase in the frequency of
micronucleated polychromatic erythrocytes.
The results indicate that isopentyl p-methoxycinnamate
does not induce chromosomal damage to the mitotic apparatus in bone
marrow cells of mice.
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