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EC number: 275-702-5
CAS number: 71617-10-2
Human breast milk samples were taken from six women and
examined for the presence of sunscreen agents Homosalate (HMS),
Isopentyl p-methoxycinnamate (IMZ), Benzophenone-3 (BP-3),
Methylbenzylidenecamphor (MBC), Octyl Dimethyl PABA (DABI) and 2
-ethylhexyl 4- methoxycinnamate (OMZ). It has been reported that up to
2% of the applied substances can be absorbed via the skin according to
manufacturers information. Glass-columns filled with differently
acitvated silica gel were used for the extraction of each of the 10 ml
milk sampIes. The extracts were cleaned by gel permeation
chromatography, afterwards reduced to a volume of 150 [ll and
quantitatively analysed by Capillary Gaschromatography/ Mass
Spectrometry in the SIM-mode. BP-3 and 2 -ethylhexyl 4 -methoxycinnamate
were unambiguously detectable in five of the six investigated samples at
a concentration range between 16 and 417 ng/g (fat basis). However,
isopentyl p-methoxycinnamate was not detected in any of the samples.
This information would add some support to the dermal absorption study
in humans in which it was concluded that dermal absorption of isopentyl
p-methoxycinnamate did not occur.
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