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EC number: 275-702-5
CAS number: 71617-10-2
net weight of the test substance [mg]
test concentration [mg/L]
respiration rate [mg/L*h]
respiration inhibition [%]
The toxicity of the test substance to microorganisms was tested in
the activated sludge respiration inhibition test (according to OECD
guideline no. 209). Three different concentrations as well as a positive
control (3,5-dichlorophenol) in 2 different concentrations and a vehicle
control (inoculum without adding any substance) were tested. No
significant effect on the respiration rate (compared to the control with
untreated inoculum) was observed after 3 h of exposure to 100 and 1,000
mg/L. At the highest test concentration of 10,000 mg/L, the respiration
rate was decreased by 10% compared to that of the control.
An EC50 could not be determined, but it can be deduced
form the experiment that this value must be higher than 10,000 mg/L.
The positive control compound induced an inhibition of respiration
of 16% and 70%, when tested at the concentrations of 1 and 20 mg/L,
respectively, thereby ensuring the validity of the test system and the
sensitivity of the activated sludge used in this test.
No inhibition of respiration was observed up to a concentration of 1000 mg/l.
The toxicity of the test substance was tested in the activated
sludge respiration inhibition test (according to OECD guideline no. 209).
A NOEC of >1,000 mg/L was determined after an exposure period of
No inhibition of respiration was observed up to a concentration of 1,000 mg/L (NOEC). The EC50 is > 1000 mg/L.
toxicity of isopentyl p-methoxycinnamate to aquatic micro-organisms was
tested in an activated sludge respiration inhibition test according to
OECD 209. In this test three different concentrations (100, 1,000, and
10,000 mg/L) as well as a positive control (3,5-dichlorophenol at 1 and
20 mg/L) and a control (inoculum without adding any substance) were
tested using an exposure period of 3 h. An inhibition of 10% was
observed at the highest test concentration of 10000 mg/L. Thus, the
NOEC(3h) is 1000 mg/L and the EC50(3h) is > 10000 mg/L.
supporting study is also available for the read across substance2-ethylhexyl
read across substance has a similar structure to isopentyl
p-methoxycinnamate, and measured physico-chemical data for the two
substances is also similar. The toxicity of the two substances in the
environment is therefore likely to be similar and read across between
the two is considered to be acceptable.
microbial toxicity of the structurally similar substance 2-ethylhexyl
4-methoxycinnamate was assessed in a GLP study according to OECD 209. In
the 30 min exposure period no inhibition of respiration was observed up
to the highest tested concentration of 1000 mg/L. The NOEC(30min) is >=
1000 mg/L. The result of the activated sludge respiration inhibition
test of 2-ethylhexyl 4-methoxycinnamate supports the assessment for
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