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EC number: 275-702-5
CAS number: 71617-10-2
The potential reproductive toxicity of 2-ethylhexyl
4-methoxycinnamate, a compound that is structurally similar
p-methoxycinnamate, was investigated in a two-generation
reproductive toxicity study in rats.
this study, wistar rats (25 animals per sex and dose group) continuously
received the test compound in the diet through two successive
generations at nominal doses of 150, 450, or 1,000 mg/kg bw/d. OMC had
no adverse effects on oestrous cycles, mating behaviour, conception,
parturition, lactation and weaning, sperm and follicle parameters,
macropathology, and histopathology of the sexual organs.
mg/kg bw/d reduced parental food consumption and body weight (-14% to
-16% in males, -4% to -5% females), increased liver weight, produced
hepatic cytoplasmic eosinophilia and erosion/ulceration of glandular
stomach mucosa, and led to a slightly decreased implantation rate in the
top dose F0 and F1 dams. The high dose F1 and F2 pups had reduced
lactation weight gain and organ weights and delayed sexual maturation
landmarks. There was no evidence of a selective influence of the test
compound on pups' sexual landmarks.
NOAEL (no observed adverse effect level) is 450 mg/kg bw/d for fertility
and reproductive performance, for systemic parental and developmental
to the high degree of structural similarity between isopentyl
the negative findings obtained with 2-ethylhexyl
in this study suggest that isopentyl
would also not show any reproductive or developmental toxicity.
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