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EC number: 275-702-5
CAS number: 71617-10-2
The acute toxicity of isopentyl p-methoxycinnamate
after dermal application to rats was studied.
Isopentyl p-methoxycinnamate was administered to 4
groups of 5 male and 5 female Sprague-Dawley rats each. The test
substance was applied once to the dorsal skin of the rats in doses of
2,500, 5,000, 10,000, and 20,000 mg/kg bw.
Methods and investigations performed were in
conformance with OECD guideline no. 402, "Acute Dermal Toxicity".
The test substance did not cause any alterations or
toxic signs in the animals, except of a slight reduction of body weight
gain in the first week. No test substance-related morphological lesions
were observed at necropsy.
The LD50(dermal, 14 d) was determined to
be greater than 20,000 mg/kg bw. Thus, isopentyl p-methoxycinnamate was
shown to possess a low degree of toxicity when
administered at single dermal doses to male and female rats.
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