Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 206-581-9
CAS number: 355-37-3
In a key
guideline (OECD 421) oral reproductive/developmental toxicity screening
test (Charles River Laboratories Den Bosch BV., 2017e), the test
material (1,1,1,2,2,3,3,4,4,5,5,6,6-tridecafluorohexane) formulated in
1% aqueous carboxymethyl cellulose with 3% Tween 80 was administered by
daily oral gavage to male and female Wistar Han rats (10/sex/dose) at
dose levels of 0, 100, 300 and 1000 mg/Kg. Males were treated for 2
weeks prior to mating, during mating, and up to the day prior to
termination (for 29 days). Females that delivered were treated for 2
weeks prior to mating, during mating, during post-coitum, and during
13-15 days of lactation (i.e. up to the day prior to scheduled necropsy;
for 50-64 days). Two females that failed to deliver healthy offspring
were treated for 43 or 53 days.
no treatment-related changes in the in-life parameters examined in this
study up to 1000 mg/Kg (i.e. mortality, clinical appearance, body weight
and body weight gain, food consumption). Males treated at 1000 mg/Kg had
statistically significantly lower weights (absolute and relative to body
weight) of the seminal vesicles than controls. It could not be excluded
that this was related to treatment. However, as the mean value, about
20% lower compared to concurrent controls, remained within the normal
range, and reproductive performance was not affected, the lower seminal
vesicle weight at 1000 mg/kg was considered not adverse.
treatment-related changes were noted in serum thyroid hormone T4 in
males, remaining organ weights (testes, epididymides, prostate,
thyroid), or findings at macroscopic and microscopic examination
(testes, epididymides, ovaries, thyroid) up to 1000 mg/Kg.
the results observed, the systemic toxicity No Observed Adverse Effect
Level (NOAEL) was determined to be at least 1000 mg/Kg.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again